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Several species of plants have been selected for testing as nootropic agents because of their use in traditional medicine, and research has already identified several promising natural substances that could act as cognitive enhancers (Table 1) [3,165,166]

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10.1016/j.mri.2012.05.001 22 FengX.GuoJ.SigmonH

111,197,198 The mitochondrial apoptosis pathway is intricately linked to MOMP, which is predominantly regulated by BCL-2 family proteins, though it can also be triggered by the mPTP

If the number of registrants requesting to speak is greater than can be reasonably accommodated during the scheduled open public hearing session, FDA may conduct a lottery to determine the speakers for the scheduled open public hearing session

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