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These chains can be attached to PARPase itself (self-PARylation) or other proteins involved in DNA repair, gene expression regulation, and cellular stress response, a process known as poly-ADP-ribosylation (PARylation) [141]

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doi:10.1186/s12970-018-0247-6 Sikiric P, Drmic D, Sever M, et al

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Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: an ex vivo and in vivo study using an NC/Nga mouse model

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