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PMID: 37299549

High trans-fat diet-induced weight gain, liver inflammation evidenced by an increased expression of TNF- and IL-1, and liver collagen production are decreased in mice with hepatocyte-specific deletion of gene Hif1a compared to wild-type mice [202]

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Matschke J., Ltgehetmann M., Hagel C., Sperhake J.P., Schrder A.S., Edler C., Mushumba H., Fitzek A., Allweiss L., Dandri M., Dottermusch M., Heinemann A., Pfefferle S., Schwabenland M.S., Magruder D., Bonn S., Prinz M., Gerloff C., Pschel K., Krasemann S., Aepfelbacher M., Glatzel M

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Chronic Toxicity No-observed-adverse-effect level (NOAEL): 272 mg/kg/day

Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response