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GHRH analogues (CJC-1295, Sermorelin, Tesamorelin) bind the GHRH receptor on pituitary somatotrophs and amplify the amplitude of endogenous GH pulses because GHRH-R activation drives cAMP/PKA-mediated GH synthesis and release

SOD3, as an antioxidant immobilized in the extracellular space, was used to protect cells and biomolecules from superoxide-induced damage and to protect the biological activity of nitric oxide by inhibiting the diffusion restriction reaction between NO and superoxide

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