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10.1089/ars.2021.0063 52 KarimiP.IslamiF.AnandasabapathyS.FreedmanN

One Prx isoform, PrxIII, is exclusively detected in mitochondria

Delivery of selenium to selenophosphate synthetase for selenoprotein biosynthesis

By delineating the copper-PDK1-AKT/-catenin-TCF4-ATP7B axis, the study provides a mechanistic foundation for combining Wnt inhibitors with copper ionophores to target therapy-resistant malignancies

IV glutathione helps calm this internal fire and restore functional balance
