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The HCN channel allows for flow of positively-charged ions, particularly potassium, out of the neuron, lowering its voltage potential and making it harder for the neuron to fire action potentials

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[10] GPX1 Glutathione peroxidase reduces hydrogen peroxide radicals (H2O2) and lipid peroxides to water and lipid alcohols and in turn oxidizes glutathione to glutathione disulfide