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Sandhir, R., Halder, A

doi: 10.1002/acn3.177

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It's a question that comes up a lot, and the short answer is that high B12 levels by themselves don't typically cause symptoms

The kynurenine (KYN) pathway (KP) is of particular importance because it is inducted by systemic low-grade inflammation in peripheral tissues, producing metabolites that are neuroactive (i.e., modulating glutamatergic and cholinergic neurotransmission), neuroprotective, or neurotoxic

Neurological & CNS Research Investigational findings have documented modulation of dopaminergic and serotonergic pathway activity