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If not treated immediately, convulsions with simultaneous hypoxia, hypercarbia, and acidosis plus myocardial depression from the direct effects of the local anesthetic may result in cardiac arrhythmias, bradycardia, asystole, ventricular fibrillation, or cardiac arrest

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Investigations suggest that this interaction may stimulate periodic bursts of growth hormone release through intracellular signaling events

doi: 10.1002/mrm.25360 34 ZhangJMaoSGuoYWuYYaoXHuangY