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doi: 10.3390/biomedicines10010076 13

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Other biomarkers of gut barrier failure Zonulin is a human protein that was originally identified in the intestine and shares significant structural similarities with a Vibrio cholera toxin called zonula occludins toxin (Zot) [230]

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Nevertheless, most first-line drugs for the treatment of those disorders target the serotonin and/or dopamine systems either directly (e.g., in depression) or indirectly via modulation of GABA-A receptors

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The increased expression of p53 and p73 protein could enhance the sensitivity of cancer cells to treatment

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