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doi: 10.1097/FJC.0000000000000058 56

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Manuscript source: Invited manuscript Peer-review started: August 28, 2018 First decision: October 16, 2018 Article in press: November 26, 2018 Specialty type: Biochemistry and molecular biology Country of origin: France Peer-review report classification Grade A (Excellent): 0 Grade B (Very good): B Grade C (Good): C Grade D (Fair): 0 Grade E (Poor): 0 P- Reviewer: Al-Haggar M, Cheng TH S- Editor: Ma YJ L- Editor: A E- Editor: Wu YXJ Contributor Information Caroline Demarquoy, DATSA 71 - Foyer Marie-Jos Marchand, 5 alle du Carrouge, Sennecey-le-Grand 71240, France

Figure 4a, b demonstrates examples of clearer skin in both inflammatory and non-inflammatory blemishes from baseline versus week 12 in subjects in the study agent group