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NAD Modulates DNA methylation and cell differentiation

Science (1992) 256:2258

proposed a nanocluster, which integrated catalase (CAT) with MnO 2 to realize CAT-triggered oxygen release and Mn 4+ -assisted GSH exhaustion, accompanied by abundant 1 O 2 accumulation, achieving a remarkable anticancer performance characterized by GSH depletion-improved PDT ( FIGURE 6 Instead of applying light and photosensitizers to achieve efficient cancer therapy, SDT employs ultrasound (US) and sonosensitizers to trigger 1 O 2 or OH generation, exerting a crucial role in ablation of tumor tissue that is hard to reach through light irradiation

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Wang M, Tan G, Eljaszewicz A, Meng Y, Wawrzyniak P, Acharya S, Altunbulakli C, Westermann P, Dreher A, Yan L, Wang C, Akdis M, Zhang L, Nadeau KC, Akdis CA

Cost-utility analysis of deferasirox compared to standard therapy with desferrioxamine for patients requiring iron chelation therapy in the United Kingdom