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New Phytol 140:173184

Although it is not exactly clear how GPx1 upregulation is affecting NMDA activity following kainic acid, exposure of GPx1 overexpressing neurons grown in culture caused an accumulation of GSSG in the media, compared to the effects of kainic acid on wildtype neurons

Shim KS, Ferrando-Miguel R, Lubec G (2003) Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimers disease

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Its pathophysiology is centered around the accumulation of a highly active intermediate compound, N-acetyl-p-benzoquinone imine (NAPQI), which is normally metabolized by glutathione
Supplementary Video 1a (download AVI U-2 OS cells stably expressing eGFPpaxillin and transfected with scrambled siRNA (siCtrl) were monitored via live-cell TIRF microscopy (control to movie 1b)
