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Studies have shown that high-affinity ETGE (K d ~ 5 nM)- and low-affinity DLG (K d ~ 1 M)-binding motifs exist and coordinate Nrf2-KEAP1 binding [281,282,283,284]

doi: 10.1210/er.2008-0027 3 OlarescuNCGunawardaneKHansenTKMollerNJorgensenJOL

Glu, the most abundant excitatory neurotransmitter in the human brain, also plays a major role in synapsis where it is released from pre-synaptic cells, and then binds to post-synaptic receptors thus inducing activation

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Ferroptosis can be significantly improved by inhibiting ACSL4 and LPCAT3

A., Moussavi-Harami F., Buckwalter J