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Comprehensive toxicology evaluations reveal that the compound does not affect food intake, body temperature regulation, or basic physiological parameters at effective doses in animal models, indicating that its metabolic effects occur through specific pathway modulation rather than general physiological disruption

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Zhao Y, He A, Zhu F, Ding M, Hao J, Fan Q, Li P, Liu L, Du Y, Liang X, Guo X, Zhang F, Ma X (2018) Integrating genome-wide association study and expression quantitative trait locus study identifies multiple genes and gene sets associated with schizophrenia

References National Comprehensive Cancer Network

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation