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However, these approaches face critical delivery challenges, including poor tumor penetration, rapid systemic clearance, and off-target toxicity, necessitating nanomaterials-mediated targeted delivery systems to achieve tumor-specific accumulation and enhanced therapeutic precision

Therefore, targeting the HIF1-c-MYC-PGC1 pathway enhances thermogenesis in beige adipose tissue, thereby providing a potential therapeutic strategy to mitigate obesity and metabolic disorders associated with high-fat diets [142]
In addition, there was also a significant reduction in VAS score pain scale, with severe pain reported in 40.2% at baseline to 3.6% at 6 months
Feldbrugge L, Splith K, Kammerer I, Richter S, Riddermann A, Ortiz Galindo SA, et al

doi: 10.3109/19396368.2012.689923 56 OluboyoAAdijehROnyenekweCOluboyoBMbaeriTOdiegwuCet al
