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doi: 10.1073/pnas.1819728116 98 ZhuSZhangQSunXZehHJLotzeMTKangRet al

Development of an in vivo murine model to evaluate the efficacy of small molecule inhibitors for the treatment of leukemic cells with activated MAPK/ERK signaling

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The metabolic plasticity of cancer is not restricted only to cancer cells but extends throughout the TME (184, 185), as seen in CAFs that secrete lactate, lung mesenchymal-derived cells that transfer lipids, suppressing the functioning of NK cells, and arginine-depleting collagen-producing TAMs, leading to the suppression of CD8 + T cell functions