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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

A common view is that increased IGF-I bioactivity depends on a higher IGF-I/IGFBP-3 molar ratio during puberty

Comparison of the effects of calcium channel blockers plus iron chelation therapy versus chelation therapy only on iron overload in children and young adults with transfusion-dependent thalassemia: a randomized double-blind placebo-controlled trial

Curcumin showed a protective antioxidant effect against gentamycin-induced oxidative stress documented by alleviated lipid peroxides, increased levels of superoxide dismutase and glutathione, increased expression of Bcl-2, a protein protecting against oxidative stress, suppressed proapoptotic Bax, and suppressed executioner caspase in apoptosis, caspase-3

doi: 10.1002/iub.1616 54 MandalPKSeilerAPerisicTKllePBanjac CanakAFrsterHet al