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Compared to the complete human IGF-I sequence, an addition of the rhLR3IGF-1 includes the substitution of an Arg for the Glu at position 3 (hence R3)and a13 amino acid extension peptide at the N-terminus

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Unfortunately I rarely see this point explained in textbooks

Frolkis, A

Pusic KM, Kraig RP, Pusic AD

Notably, one study found that several hepatic genes, including MT1 and various HSPs (Hspca, Hspcb, Hspa8), were expressed at approximately twice the normal levels in a HFD mouse model [99]