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In a controlled postmarketing dose-response study, patients treated with doses of alprazolam greater than 4 mg per day for 3 months were able to taper to 50% of their total daily maintenance dose without apparent loss of clinical benefit

In a phase-I, dose-escalation trial, the co-administration of temsirolimus plus radiotherapy and TMZ to patients with newly diagnosed GBM was associated with several adverse events, including increased infectious risks [406]

LCMS analysis was conducted using a Vanquish UHPLC system (Thermo Fisher Scientific) coupled to an Orbitrap Exploris 480 mass spectrometer (Thermo Fisher Scientific)

7D), and increased activity of the SMAD1 and SMAD9 regulons (Supplementary Fig