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Vasodilatation, known for years as one of the causes of migraine attacks, is still mentioned in the newest research [53]

So, TMAO can play an essential role in regulating inflammation and result in protective or causative effects, stimulating or attenuating the production of inflammatory cytokines that can attract more immune cells, forming a vicious circle that leads to foam cells formation and atherosclerosis development (81)

Moreover, long-term safety should be explored to assess the feasibility of using herbal extracts as a long-term therapeutic option

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Wnek agrees, and explains that "because of how deep these fat cells lie, it may be hard for caffeine in topical products to reach the target site to work." "Some benefits may be immediate, resulting from a temporary vasoconstriction of blood vessels, such as what occurs with caffeine, in which case using a cream in the days prior to a vacation may provide some instant benefit," said Dr