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Cardiovascular evidence SUMMIT showed a 38% reduction in cardiovascular death or worsening heart failure in obese HFpEF patients

Korsmo HW, Jiang X

Bourgeois B, Madl T (2018b) Regulation of cellular senescence the FOXO4-p53 axis

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The simultaneous interaction with the endogenous Ub-E2-E3 complex and the protein of interest results in the generation of an Ub-E2-E3-neosubstrate complex, ultimately leading to ubiquitinylation and degradation of target protein