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(DOCX) Acknowledgments We thank Greg Fairn and Masashi Maekawa for reagents and guidance in characterizing sphingomyelin abundance and localization in the worm

The research-grade standard is lyophilized powder stored at 20C until reconstitution, then refrigerated at 28C and used within 28 days

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The inflammatory variant may present with systemic symptoms, such as fever and weight loss and leukocytosis

Corresponding Author: Department of Oral Medicine & Pathology and Hospital Dentistry School of Dentistry, University of Athens 2 Thivon St., Goudi 11527, Athens Greece Phone: +30 210 7461304