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FOXO4-DRI and related constructs have been studied as tools to better understand these mechanisms, potentially offering models to examine how FOXO-related signaling interacts with neurodegenerative processes

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10.1016/j.bbrc.2005.09.128 Biochem

310 Similar effects are observed after transgenic deletion of Ccl2 specifically from astrocytes, which showed little effects early in EAE but demonstrated that astrocyte Ccl2 sustains disease symptoms and inflammation during chronic EAE, making it a therapeutic target

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Thus, it is hypothesized that increases in the GLT-1 transporter, as reported for ASA (Israel et al., In the present studies, we investigated whether a reduction of ethanol intake induced by NAC follows the activation of the hippocampal Nrf2-ARE antioxidant signaling pathway, which could be prevented by inhibition of the xCT cystine-glutamate transporter and by inhibition of the glutamate presynaptic metabotropic mGlu2/3 receptor