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Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

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Most patients need a series of 34 treatments spaced one month apart to achieve best results, with maintenance sessions every 612 months

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Additionally, navitoclax is almost impenetrable to the blood brain barrier, thus, the current drugs are not able to reach the brain parenchyma (67)

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In this process, single-stranded DNA bound by Rad51 invades the sister chromatids to search for homologous sequences and accomplishes repair through sequence synthesis and exchange (Moynahan and Jasin, 2010)

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