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However, unlike Navitoclax, which can be administered orally and has good bioavailability [102], ABT737 poorly dissolves in water, and its biological availability is low [87]

(Table 5)

doi: 10.3389/fendo.2023.1306470, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Samuels M

Maslennikova et al

One limitation is that, in a variety of cell types, Nox transcript levels at baseline do not necessarily predict stimulus-induced activation of the enzymes, and opposing functions of various enzymes have been detected under different physiological conditions