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4-chloro-3-hydroxybutyronitrile is synthesized from epichlorohydrin in an aqueous hydrogen cyanide solution 4-chloro-3-hydroxy butyric acid alkyl ester is then synthesized from the 4-chloro-3-hydroxybutyronitrile in the presence of an alcohol and a sulfuric acid catalyst the racemic 4-chloro-3 -hydroxy butyric acid alkyl ester is hydrolyzed in an aqueous solution using an enzyme, thereby preparing (R)-4-chloro-3-hydroxy butyric acid alkyl ester

10.1016/j.jnutbio.2021.108600 67 JackC

Therefore, the use of systematic network pharmacology to identify and optimize screening biotargets, functional processes, and molecular pathways of L-carnitine in PCOS treatment is necessary before preclinical or clinical studies

HIZLI TESLMAT

Clin Immunol 1999;92:103-10

(2) Other nonclinical evidenced herbs defined as doubtful in Section 3 were excluded in this table