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Mash DC, Pablo J, Ouyang Q, Hearn WL, Izenwasser S

Likewise, there is greater proliferation of human umbilical vein endothelial cells (HUVECs), significantly promoted migration of HUVECs (transwell assay), and the upregulated expression of VEGF-a, and accelerated vascular tube formation in vitro (Huang et al., 2015)

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The published research on oral B12 bioavailability consistently shows around 1% absorption meaning of a 1000mcg oral dose, only about 10mcg actually reaches your cells