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2 Effects and mechanism of natural products in acetaminophen-induced hepatotoxicity A number of phytochemicals have been identified to have hepatoprotective activity, such as silymarin for the treatment of liver poisoning, chronic hepatitis and cirrhosis (Abenavoli et al., 2018), resveratrol and curcumin for the relief of liver damage, etc., (McGill et al., 2015

[168], he proposed that NO may bind to the enzymes of mitochondrial ETC, such as NADH succinate oxidoreductase, NADH ubiquinone oxidoreductase, and cis aconitase and induce uncoupling of OXPHOS followed by the inhibition of glycolysis [66] and depletion of ATP in the cells [169]

Altered bile acid metabolome in patients with nonalcoholic steatohepatitis

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