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The safest approach is sequential dosing delay TB-500 until the post-surgical anticoagulation window ends (typically 24 weeks), or use mechanical compression devices for DVT prophylaxis during the TB-500 administration phase instead of pharmacologic anticoagulation

Additionally, HCG is contraindicated in cases of precocious puberty, as it may exacerbate early sexual development, especially in prepubertal males receiving it for cryptorchidism

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Dosage Recommendations : Typical recommended dosages range from 300 to 500 micrograms, taken a few times a week, rather than continuously