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Autophagic/lysosomal dysfunction in Alzheimers disease

There are a few new neurons, but not that many unless you're a mouse, frankly

Benito-Villalvilla C, de la Rocha-Munoz A, Lopez-Abente J, Eggel A, Bottoli I, Severin T et al (2023) Ligelizumab impairs IgE-binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN-alpha production and FOXP3(+) Treg generation

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paper in Pharmaceutical Research showed near-zero permeation of GHK-Cu through intact human skin, with 134 nanomoles of peptide reaching the dermal layer once microneedles created the channels 3