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Advanced insulin resistance, mitochondrial damage from chronic oxidative stress, or inflammatory states can create barriers to AMPK activation and NAD+ utilization that require co-interventions (caloric restriction, anti-inflammatory compounds, or antioxidant support)

Keywords: cutaneous manifestation of vitamin b12 deficiency, adisonian mimick, vitamin b12 deficiency symptoms, cutaneous hyperpigmentation, hyperpigmentation Introduction The deficiency of vitamin B12 can cause specific skin manifestations, such as hyperpigmentation, vitiligo, angular stomatitis, and hair and nail changes [1]

However because vitamin B12 is primarily found in animal products such as milk, cheese, and eggs, vegans are at higher risk of having a vitamin B12 deficiency

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