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Prolotherapy (short for "proliferation therapy") is a regenerative injection treatment that involves injecting an irritant solution into damaged or weakened ligaments, tendons, or joints

Clinical use: Supervised protocols at medical clinics involve subcutaneous injection over 4 to 8 weeks, with dosing individualized to injury type and severity

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Furthermore, having already knowledge on natural history and validated tools for outcome assessment, placebo-controlled trials can be designed in a way that conclusions are provided much faster and with less insecurity, enabling all patients to undergo treatment quickly [259]

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Komaroff AL, Bateman L