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Role of glutamate and NMDA receptors in Alzheimers disease

At the molecular level, Bmal1 stands out as a central regulator of genomic surveillance, preventing the replication of DNA-damaged cells through its transcriptional modulation of repair genes, activation of p53, and the imposition of rhythmicity on checkpoint mechanisms (Kiessling et al., 2017

The KRAS G12V /MYC tumor cells also displayed the Warburg effect, as revealed by a higher rate of glycolysis quantified by Seahorse metabolic flux experiments (Fig

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