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Cold Spring Harb Perspect Biol (2009) 1(6):a001651

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Therefore, US FDA-approved oral activators of NRF2, such as dimethyl fumarate (DMF) [20,21] and simvastatin [22,23], are attractive targets for drug repurposing in SCD

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Abbreviations DOX: Doxorubicin DIC: DOX-induced cardiomyopathy LIG: Ligustrazine PIEZO1: Piezo type mechanosensitive ion channel component 1 TMBIM6: Transmembrane BAX inhibitor motif containing 6 PHB2: Prohibitin 2 ATP: Adenosine triphosphate ER: Endoplasmic reticulum MQS: Mitochondrial quality surveillance UPR: Unfolded protein response References Teraoka K, Hirano M, Yamaguchi K, Yamashina A