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The peptide normalized enzyme markers of muscle damage including creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase, indicating restoration of muscle cell membrane integrity and metabolic function

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for others, it may take up to 90 days to notice any visible results

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K-means clustering of amplicon sequence variant data confirmed that 5-Amino-1MQ treatment generated a distinct cecal microbiome profile from all other treatment groups including diet-switched vehicle controls indicating that NNMT inhibition produces microbiome changes that are separable from those produced by dietary composition alone