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Front Physiol 12:680544 Deng F, Zhao BC, Yang X et al (2021) The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis

[DOI] [PubMed] [Google Scholar] Deshpande A

doi: 10.1016/j.ecoenv.2024.117569

A fourfold increase in Sp1 O -GlcNacylation (caused by inhibition of the enzyme O -GlcNac-- N -acetylglucosaminidase) resulted in a reciprocal 30% decrease in the level of serine/threonine phosphorylation of Sp1

The resulting metabolite is exported via the portal vein through interacting with multidrug resistance proteins until it enters the bloodstream and reaches tissues, where it is taken up by the RFC system or by folate receptors

This is an unprecedented global health crisis, which imposes a considerable burden on health systems