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Several factors are established to affect the transduction signals of VEGF, which include P13K/AKT pathway during hypoxia conditions, RAS/RAF/MAPK (ERK) pathway during normoxia and probably via the activation of EGFR in non-hypoxia conditions

Thus, our findings are not surprising but suggest that future studies investigating IL-8 signaling could improve the understanding of sarcoidosis pathogenesis and potentially phenotypes

Curr Opin Clin Nutr Metab Care 15:122126

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