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Dosage should start at 50 mg/kg/day, and be increased slowly to a maximum of 3 g/day (30mL/day) while assessing tolerance and therapeutic response

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DERAVE, W

Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-kappaB/COX-2/RANKL signaling in Sertoli cells

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The expression of occludin, a protein involved in maintaining tight junction barrier properties, glial cell-derived neurotrophic factor (GDNF), associated with spermatogonial self-renewal, and transforming growth factor-beta (TGF-), implicated in injury repair processes, were analyzed in Sertoli cells