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In turn, oxidative stress can increase the formation of drug-protein adducts by favoring the generation of reactive metabolites of drugs, thus facilitating protein haptenation and subsequent activation of the immune system or other toxic effects

Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages

This is one reason chronic alcohol use is associated with oxidative damage and conditions like fatty liver

doi: 10.1016/j.bcdf.2019.100182 147

Various extraction techniquesincluding hot water, ultrasonic assisted, and microbial fermentation methodshave been developed to isolate BSPs, with extraction parameters significantly influencing its structural features

Brand: GlaxoSmithKline