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Description
Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature
This was mirrored by reduced MuSC senescence and increased mitochondrial respiration and membrane potential in MuSCs, paralleled by improved fitness and exercise performance

This typically resolves once the UTI is treated, although people with dementia may experience a permanent increase in symptoms
Copyright 2009, an Imprint of Elsevier

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