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Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature

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This was mirrored by reduced MuSC senescence and increased mitochondrial respiration and membrane potential in MuSCs, paralleled by improved fitness and exercise performance

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This typically resolves once the UTI is treated, although people with dementia may experience a permanent increase in symptoms

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Copyright 2009, an Imprint of Elsevier

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