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What the Authoritative Sources Say About B12 Deficiency and Supplementation The National Institutes of Health Office of Dietary Supplements publishes the most thorough citation-backed overview of vitamin B12 its role in red blood cell formation and neurological function, the populations most at risk for deficiency (older adults, people on long-term metformin or proton pump inhibitors, vegetarians and vegans, people who have had gastric bypass surgery), and the recommended daily intake at each life stage

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Proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) are commonly prescribed after bariatric surgery and can impair the release of B12 from food proteins, reducing absorption of food-bound B12 over time

Adequate B12 levels are associated with better cognitive function, memory, and concentration

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