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Authors also often mention that mutations in genes coding ion channel proteins like CACNA1A, ATP1A2, and SCN1A, which encode voltage-gated calcium channels, are singled out in studies as an essential link in headache [64]

Science 363 , 13451349 (2019)

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Charpentier AM, Conrad T, Sykes J, Ng A, Zhou R, Parent A,

Despite numerous clinical studies supporting the positive effects of CoQ10 in migraineurs, it appears that the mechanisms through which it acts in this group are not entirely clear