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In fact, the cysternae of the endoplasm reticulum is the only part of the cell with a relatively high ratio of GSSG/GSH

[5] During the reaction, an amino acid residue in the enzymes active site acts as a general base and abstracts a proton from C-3, leading to the formation of the cis-2,3-enediol intermediate

Specifically, the combination of hydrogen peroxide and superoxide results in the formation of hydroxyl radicals [63]

PMID 21901556

Theranostics 9(8):22682281

A fourth stage (prevalence equilibrium) has been proposed in which the prevalence slope plateaus due to demographic shifts in an ageing IBD population, but it has not yet been evidenced