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As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

Sometimes, B12 deficiency triggers gastrointestinal symptoms, such as appetite loss, sore tongue and mouth, stomach discomfort, heartburn, nausea and even vomiting (Sobczyska-Malefora et al., 2021)

Lifestyle: Stress, frequent exercise, and a high metabolism can all shorten the duration of results

doi:10.1016/0049-3848(94)90235-6 Apitz-Castro R, Badimon JJ, Badimon L

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In case of overdose, drowsiness, visual disturbances, vomiting, lowering of blood pressure, muscle tremors are possible