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The clinical presentation is a flat or slightly raised brown-to-black macular lesion, generally solitary, which occurs predominantly in the buccal mucosa of young black females

Preclinical studies in female Syrian hamsters have characterized bremelanotides effects on solicitational behavior and sexual receptivity, demonstrating that MC4R agonism in hypothalamic circuits facilitates proceptive behaviors independent of hormonal priming (PMID: 39793696)

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Murase, T., Haramizu, S., Shimotoyodome, A., Tokimitsu, I

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