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103 Insulin resistance, even in the context of normal blood glucose levels, promotes unhealthy lipid metabolism and obesity, activates inflammatory pathways, and reduces NO production, promoting endothelial dysfunction and accelerated atherosclerosis

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2021 Aug 19;3(8):e0515

(2018) showed that the pathophysiology of hepatic IR injury is primarily marked by lipid metabolic reprogramming, which results in a secondary effect of inflammation, thereby highlighting the role of lipid metabolism in disease pathogenesis