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This tiered structure enables sponsors of all sizes from global pharmaceutical companies executing 40-country pivotal programs to emerging biotechs running first Phase II studies to access DCT capabilities at the appropriate scale and cost point for their operational context

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Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress

Additionally, the upregulation of ribosomal proteins enhances protein synthesis, and glycolytic enzyme overexpression boosts energy production, collectively contributing to the parasites survival and resistance ( A comparative overview of resistance mechanisms across major antileishmanial drugs is provided in Table 3, highlighting recurrent themes such as transporter upregulation, metabolic adaptations, and genetic mutations