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Moreover, consuming probiotics and prebiotics linked to certain genes that inhibit TMA-producing bacteria has also been shown in some studies to help control the generation of TMAO [112, 113]

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The generation and release of vasoactive factors by endothelial cells, such as endothelium-derived relaxing factors (EDRFs) and contracting factors (EDCFs), are vital for the maintenance of normal physiological conditions, and disturbances to these factors are known to increase the incidence of endothelial dysfunction [2,3,4]

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