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The most commonly reported events in active arms were mild and transient: injection site reactions in some subcutaneous subjects, occasional headache, and in some oral dosing arms, minor gastrointestinal tolerance issues

No adverse reactions were reported in treated animals

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A meta-analysis confirmed that administering folate, vitamin B12, and vitamin B6 can help decrease serum homocysteine levels

This is likely because estrogen moderates the release of norepinephrine, reducing activation of the HPA axis during a stressful event