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This has in fact been done in mice (401)

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Additionally, inflammation-induced oxidative stress can degrade drugs 70,74,75

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Fabry (stored globotriaosylceramide) using targeted enzyme replacement therapy with alpha-galactosidase A (e.g., Algalsidase alpha (Replagal marketed by Shire), Algalsidase beta (Fabrazyme marketed by Genzyme), or with substrate inhibition of glucosylceramide synthase with imino sugars (e.g., miglustat (Zavesca marketed by Actelio n ) = N-butyl- deoxynojirimycin (NB-DNJ), N-butyl-galactosyl-deoxynojirimycin (NB-DGJ), N-(5- adamantane-1-yl-methoxypentyl) (AMP-DNJ), AMP-DNM or MZ-21 and MZ-31 from Macrozyme), or with glucosylceramide analogs (e.g., Genz 112638: d-threo- ethylendioxyphenyl-2-palmitoylamino-3-pyrrilidino-propanol), or with chaperone therapy (ATlOOl, migalastat hydrochloride (to be marketed as Amigal by Amicus Therpeutics with chemical names 3 ,4,5-piperidinetrio 1 , 2-(hydroxymethyl) , hydrochloride, (2R,3S,4R,5S)-, (+)-(2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5- triol hydrochloride, l,5-dideoxy-l,5-imino-D-galactitol hydrochloride)